rosiglitazone inhibits hmc-1 cell migration and adhesion through a peroxisome proliferator-activated receptor gamma-dependent mechanism.

mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. peroxisome proliferator-activated receptor gamma (pparγ) is a member of the large nuclear hormone  receptor  transcription  factor  superfamily, and  has  been  recently implicated in the anti-inflammatory response. to investigate a possible role for pparγ in human mast cells, we studied the effects of a pparγ  ligand,  rosiglitazone  (rg),  on  stem  cell  factor  (scf)-induced  migration  and fibronectin-induced adhesion in human mast cell-1(hmc-1) cells. it was found  that hmc-1 cells expressed pparγ mrna. rg inhibited scf-induced hmc-1 cell migration and fibronectin-induced hmc-1 cell adhesion, the selective pparγ antagonist gw9662 prevented the inhibitory effect of rg on hmc-1 cells. in conclusion, rg inhibits the migration and adhesion of hmc-1 cells by a pparγ-dependent mechanism.